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Possibly there are similarities among euphorb plant species
2020-08-24
Possibly there are similarities among euphorb plant species but extraction of the GW1929 present in the microsomal fraction is needed for testing their preferences for substrates. Although R. communis, E. lathyris and E. lagascae belong to the same family, the DGAT activity of their microsomal prep
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The purposes of this study are to investigate the
2020-08-24
The purposes of this study are to investigate the molecular function of DDR2, especially in cellular proliferation in prechondrocytes, and to examine the relationship between the proliferation and differentiation of prechondrocytes through both in vitro and in vivo analysis. Materials and methods
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Pathological changes in animal are powerful indicators of th
2020-08-24
Pathological changes in animal are powerful indicators of the exposure to environmental stressors. The liver serves as an appropriate organ for the study of pollutant effects because of its high capacity to accumulate pollutant and its susceptibility to histopathological damage by pollutants (Padmin
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Pyrazolopyrimidines are bioisostere of purine exhibit
2020-08-24
Pyrazolopyrimidines are bioisostere of purine exhibit promising antitumor activity by competitively binding to the ATP active site of different kinase bromophenol blue [16,17]. Several compounds of this family were found to induce apoptosis and/or reduce cell proliferation in various solid tumour a
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Previous studies reported that NE and MHPG are
2020-08-24
Previous studies reported that NE and MHPG are deeply involved in depression and that NE reuptake inhibitors are approved for use in patients with depression (for review, see [2]). We found increased hippocampal content of NE and MHPG in the CORT-treated CRTH2−/− mice (Fig. 3). In the hippocampus, a
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Moreover a ligand for fusin has recently been found the
2020-08-22
Moreover, a ligand for fusin has recently been found: the lymphocyte chemoattractant stromal-derived factor-1 (SDF-1) binds to CHO TPPU transfected with fusin and promotes secondary messenger production (Bleul et al., 1996; Oberlin et al., 1996). A new name, CXCR-4, has been proposed for the recept
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We have previously disclosed the discovery of a azaindole
2020-08-22
We have previously disclosed the discovery of a 7-azaindole-3-acetic Ac-DEVD-AFC synthesis CRTh2 antagonist chemotype 1 from HTS and its subsequent optimization to give 2 as a potent and orally bioavailable inhibitor of eosinophil shape change (SC) in human whole blood. Subsequent to disclosure of
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Another important mediator in fear learning
2020-08-22
Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b
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Fig shows graphically the abundance distributions of the ARD
2020-08-22
Fig. 3 shows, graphically, the abundance distributions of the ARD% of the investigated data with both the CPA-NRTL and CPA-UNIQUAC models, where ARD% is defined as,in which x and x are the experimental and calculated SO2 molar compositions in the liquid phase, respectively, and N is the total number
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Nowadays it is possible to detect the
2020-08-22
Nowadays it is possible to detect the AChE inhibitors by several methods such as gas chromatography-mass spectrometry [11], ion mobility spectrometry [12] and lab-on-chip devices [13,14]. However, almost all instrumental detection techniques that are able to conclusively determine the presence of th
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Ten non FH ADH probands
2020-08-22
Ten non-FH ADH probands fulfilled the diagnostic criteria of hyperabsorbers. Table 2 shows the main lipid characteristics of these subjects and of 10 non-hyperabsorber probands used for comparison. There were differences between groups in body mass index, waist circumference and triglycerides. Other
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In ER group Histopathological examination followed by Fluore
2020-08-22
In ER + group, Histopathological examination followed by Fluorescence in situ hybridization (FISH) had revealed the absence of HER2 receptors. Co-targeting of ER and HER2 appears to provide benefit without a significant increase in toxicity although formal trials have not been carried out [18]. Adop
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The knockout mice models of the DNMTs gene shed light
2020-08-21
The knockout mice models of the DNMTs gene shed light on understanding the molecular background of male infertility development. Dnmt1−/− causes demethylation of the genome (Lei et al, 1996, Li et al, 1992) (). The Dnmt3a conditional knockout mouse models exhibit spermatogenic arrest at the spermato
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Of the acidic hydroxyazoles involved hydroxypyrazole had the
2020-08-21
Of the acidic hydroxyazoles involved, hydroxypyrazole had the weakest acidic profile (pKa in the range of 6–7), although highly deprotonated at physiological pH. During hit optimization, the two pyrazole ring positions available for substitution provide an opportunity for a better exploration of the
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br Cytokines as targets for the development of drugs Since
2020-08-21
Cytokines as targets for the development of drugs Since the first scientific evidence describing the large number of cytokines and their functional roles and involvement in molecular mechanism of various diseases or disorders researchers have targeted cytokines. (Isaacs and Lindenmann, 1957), Des
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