• p as a cyclin dependent kinase

  2021-05-31

  

  p21, as a cyclin-dependent kinase inhibitor, exert significant negative regulator of proliferation, and it could be transcriptional upregulated by p53 in order to impel transient Dipraglurant arrest (Romanov et al., 2010). Using western blotting, we found that the protein expression of p21 upgrades

• br Materials and methods br Discussion To date only a

  2021-05-31

  

  Materials and methods Discussion To date, only a fraction of studies pertaining to analysis of avian semen have focused on the study of DNA, with the vast majority being associated with the effects of cryopreservation on sperm DNA integrity (Kotłowska et al., 2007, Madeddu et al., 2009, Partyk

• The ability of minor groove binding agents

  2021-05-31

  

  The ability of minor groove binding agents to inhibit the activity of DNA helicases is not without precedence. Similar effective inhibition of the unwinding of DNA by the BLM and Werner's DNA helicases by the minor groove binder distamycin A has been observed. Further, and similar to RecBCD, interc

• We examined the function of immobilised THPs by

  2021-05-31

  

  We examined the function of immobilised THPs by seeding cells transfected with DDR2-Flag on derivatised crosslinked collagen films, then detecting the phosphorylation of tyrosine 740 (Y740) on the intracellular domain of DDR2 [50]. This regulatory residue is a target for the intracellular tyrosine k

• br Conclusion The results of the present study demonstrate

  2021-05-31

  

  Conclusion The results of the present study demonstrate that cysteinyl leukotrienes LTC4, LTD4 and LTE4 cause moderate to marked whereas the dihydroxy leukotriene LTB4 causes small muscle contraction in the stomach in vitro. The LTD4-induced contraction is mediated by CysLT1 in fundus but by CysL

• Table shows all AP courses taken

  2021-05-31

  

  Table 5 shows all AP courses taken by participants, in descending order with respect to percentage of higher-order keywords. Table 5 also includes t-tests of mean differences for average CPA exam scores of participants who have taken (vs. not taken) AP courses (AP_ENGAGE), and average CPA exam score

• Previously we have shown that

  2021-05-28

  

  Previously, we have shown that complexes of protein PKs with inhibitors that comprised sulfur or selenium atoms in aromatic structures were phosphorescent at room temperature, while the long-lifetime signal emitted by the free inhibitor was negligible.34, 35, 36 This phenomenon was caused by stabili

• Although further experiments are needed

  2021-05-28

  

  Although further experiments are needed to determine definitively whether D–ETB receptor heterodimers exist, for example, by using fluorescence resonance Pseudo-UTP transfer analysis or co-immunoprecipitation of receptors, the results of the study by Zeng and colleagues appear to indicate that D–ET

• There is a functional ubiquitin association UBA domain at

  2021-05-28

  

  There is a functional ubiquitin association (UBA) domain at the N terminus of MCPIP1. Liang et al. have discovered that MCPIP1 may be a deubiquitinase and defined a novel DUB domain of MCPIP1 [22]. Ubiquitin and deubiquitin modification emerge as the key mechanisms that regulate the virus-induced ty

• This work was supported by grants from

  2021-05-28

  

  This work was supported by grants from the Institute of Cancer Research (ICR) and Biotechnology and Biological Sciences Research Council (BB/I014276/1 and BB/M013782/1). Main Text In 2006, Warburg et al. described an apparently distinct connective-tissue disorder characterized by blepharophimosi

• br Experimental procedures br Introduction Protein kinases r

  2021-05-28

  

  Experimental procedures Introduction Protein kinases represent one of the largest enzyme Deoxynivalenol in the human genome and act as signaling mediators in a variety of cellular processes (Manning et al., 2002). Because many diseases are associated with aberrant protein kinase activity, tar

• br Conclusions Cereal seeds like the seeds of

  2021-05-28

  

  Conclusions Cereal seeds, like the seeds of all plants, are responsible for the development, protection, dispersal, and nutrition of the next generation. Moreover, cereal caryopses have a high nutritional value for humans and animals. The stable and proper growth of cereal seeds is made possible

• A summary of the drug CDK hydrophobic hydrogen bonding

  2021-05-28

  

  A summary of the drug-CDK2/6/9 hydrophobic (Φ), hydrogen-bonding (H), and polar-bonding (P) interactions based upon the KLIFS residue numbers is provided in Table 5. The KLIFS system gives comparable residues from different vorapaxar the same value [77], which facilitates comparisons among differen

• We next examined the effects of substituents around the

  2021-05-28

  

  We next examined the effects of substituents around the carboxylic GLPG0634 moiety on CRTH2 binding (Table 4). The carboxylic acid moiety shared by the representative CRTH2 antagonists and is essential for the CRTH2 activity. Germinal dimethylation of the methylene moiety next to the carboxylic acid

• toremifene The COMT gene maps to chromosome q Grossman et al

  2021-05-27

  

  The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT

14724 records 631/982 page Previous Next First page 上5页 631632633634635 下5页 Last page