• br Regulation of plasma ghrelin

  2022-03-29

  

  Regulation of plasma ghrelin concentration As described above, ghrelin is primarily produced in the stomach and secreted into the blood stream. Plasma ghrelin does not significantly differ between chronic heart failure (CHF) patients and controls, although plasma ghrelin level is significantly hi

• Communication through GJ channels is

  2022-03-29

  

  Communication through GJ channels is regulated at different levels and includes GJ plaque internalization into a single cell. Those vesicles contain the membrane of both cells and th assembled Cx43. The C-terminal domain of Cx43 interacts with different peptides and proteins. However, the internaliz

• br Introduction The nature of

  2022-03-29

  

  Introduction The nature of chemotherapies is to relieve the tumor burden of the patients by eliminating cancer CID 2011756 receptor via inducing cell death, mostly regulated cell death represented by apoptosis [1,2]. Dozens of anticancer agents including clinically used ones kill cancer cells by

• The urea derivatives a e were obtained from phenoxybenzyl

  2022-03-28

  

  The urea derivatives 7a–e were obtained from 1-(3-phenoxybenzyl)-piperazine (6) by reaction of isocyanate, or triphosgene and subsequent reaction of produced carbamoyl chloride with the amine RH as shown in Scheme 2. The imidazole urea 7g was prepared by reaction of 6 with 1,1′-carbonyldiimidazole.

• br Introduction The period around birth

  2022-03-28

  

  Introduction The period around birth is a risky time for stroke in infants. Ischemic stroke has been diagnosed in about 1/4000 full-term infants (Nelson and Lynch, 2004) and perinatal stroke represents the second most frequent cause of acute seizures in this age group (Levy et al., 1985). Further

• NeuroHIV is initiated by HIV crossing

  2022-03-28

  

  NeuroHIV is initiated by HIV crossing the blood–brain barrier (BBB) to enter the CNS. This is thought to occur primarily via the transmigration of infected CD14+CD16+ monocytes (Williams, 2014), using the monocytes as “Trojan Horses” (Peluso, 1985), although some studies suggest alternate routes of

• Relative to the impact of moderate

  2022-03-28

  

  Relative to the impact of moderate PAE on markers of histaminergic neurotransmission, there were four salient observations from the studies reported here. First, it does not appear that moderate PAE affects the number of HDC-positive neurons in the tuberomammillary nucleus of the ventral hypothalamu

• Most studies of HIF have focused on its transcriptional

  2022-03-28

  

  Most studies of HIF-1α have focused on its transcriptional activity-dependent functions. However, our results indicate that the oxidative stress-related effects of mtHIF-1α occur independently of its translocation to the nucleus and do not require its transcriptional activity. In fact, several studi

• ANT located in the IMM mediates the exchange of

  2022-03-28

  

  ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions

• ICLs represent of all generated DNA adducts for cisplatin

  2022-03-28

  

  ICLs represent ICL Inducers in Cancer Therapy Nitrogen mustards with aromatic substituents (chlorambucil, melphalan) or a bioactivatable phosphoramide group (cyclophosphamide) were one of the first identified DNA crosslinkers. These agents are still used in combined schemes for the therapy of chr

• Measured physicochemical water parameters including conducti

  2022-03-28

  

  Measured physicochemical water parameters including conductivity, suspended solids and nutrient load along the studied sites (Table 1) were high compared to levels usually found in undisturbed rivers within Europe (Chapman and Kimstach, 1996). In particular conductivity, suspended solids and phospha

• br Expression profile of GPR As noted above initial

  2022-03-28

  

  Expression profile of GPR35 As noted above, initial studies indicated expression of GPR35 in rat intestine [1] and stomach [2]. Subsequent studies have confirmed significant expression levels in the small intestine, colon and stomach, and this might be relevant in the association between a GPR35

• In recent large clinical studies

  2022-03-28

  

  In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic aldehyde dehydrogenase inhibitor to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH stu

• flavin adenine dinucleotide sale Through the analysis of var

  2022-03-28

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic flavin adenine dinucleotide sale motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early p

• br Material and methods br

  2022-03-26

  

  Material and methods Results Discussion Functional characterization of naturally occurring GCK mutations in patients with impaired glucose homeostasis has widened our knowledge of the catalytic and regulatory mechanisms of this enzyme [3]. In this work, we have biochemically characterized a

15090 records 479/1006 page Previous Next First page 上5页 476477478479480 下5页 Last page